A theoretical paper published in Psychopharmacology in 2026 proposes that anxiety disorders may involve a kind of stuck pattern in the hippocampus, a brain structure central to memory and context, and that psychedelics could work by temporarily disrupting that pattern. This is a theoretical framework, not a clinical trial, and no human therapeutic outcomes are […]
In a small pilot study of seven healthy adults, Washington University researchers used fMRI to show that psilocybin dramatically disrupts functional connectivity across the brain, especially in the default mode network, the system thought to govern a person’s sense of self, space, and time. Some connectivity changes persisted for at least three weeks. Key takeaways […]
A new study reports that psilocybin changes the way the brain communicates internally, with findings pointing specifically to altered connectivity across neural networks. While the source text does not detail the study’s size, methodology, or the exact networks involved, the core finding is that the compound appears to reorganize, at least temporarily, the patterns through […]
A single dose of psilocybin appears to reduce reward-seeking behavior in rats for at least 48 hours after administration, and a new study published in the European Journal of Neuroscience now points to a specific cellular mechanism that may explain why: the increased activation of inhibitory neurons wrapped in specialized structures called perineuronal nets. The […]
New research published in June 2026 in the Proceedings of the National Academy of Sciences offers one of the clearest mechanistic pictures yet of what several psychedelic compounds have in common inside the brain. Using optical flow analysis, a technique that tracks the direction and strength of neural signal movement across the cortex, scientists from […]
A newly published hypothesis offers the most detailed mechanistic account yet of how psilocybin produces lasting changes in the brain. The paper, appearing on PubMed in May 2026, proposes what its authors call a “spatiotemporal gating” model, an attempt to resolve a longstanding puzzle in psilocybin research: how does activation of the serotonin 5-HT2A receptor […]
A study published in May 2026 in PubMed presents findings on how the brain’s electrical wave patterns propagate differently under psychedelic compounds compared to other altered states. Using data across psilocybin, LSD, DMT, and ketamine, as well as sleep and anesthesia, researchers identified novel spatiotemporal neural mechanisms that appear specific to psychedelic consciousness, suggesting these […]
A high-dose psilocybin treatment produced what researchers described as remarkable effects in an elderly patient living with dementia, according to a report surfaced by ScienceAlert in June 2025. The case is a single data point, not a clinical trial, but the researchers involved believe it warrants serious attention and structured follow-up investigation. What the Psilocybin […]