In a small controlled study of 28 healthy adults, a single 25 mg dose of psilocybin increased brain entropy during the experience, and participants reported greater psychological insight and improved well-being up to one month later. Structural imaging also showed changes in neural tract integrity. These are early findings in a healthy, non-clinical sample. Key […]
A study published in May 2026 reports that psilocybin significantly improved sleep quality in patients living with chronic cluster headache, one of the most debilitating pain conditions known to medicine. The research also observed trends toward changes in white matter microstructure as measured by diffusion-weighted MRI, a finding that is preliminary but points toward a […]
Up to half of all people who sustain a concussion will carry its effects long after the initial injury fades, living with headaches, dizziness, cognitive fog, irritability, and disrupted sleep that can persist for months or years. There are few proven therapies for this condition, and many patients are left managing symptoms without meaningful relief. […]
A study published in June 2026 in the journal Brain offers fresh support for one of the more compelling frameworks in psychedelic neuroscience: the entropic brain hypothesis. The research, authored by Robin Carhart-Harris of the Carhart-Harris Lab at UCSF and the Centre for Psychedelic Research at Imperial College London, found that increases in brain entropy […]
A randomized, controlled neuroimaging study published in May 2026 has measured what happens inside the brain when healthy volunteers take an oral combination of DMT and harmine, the two primary pharmacological constituents of the traditional brew ayahuasca. Using fluorodeoxyglucose positron emission tomography, or FDG-PET, researchers found a 12.5 percent increase in global cerebral glucose metabolism […]
A team at Penn Medicine has traced the specific serotonin receptor pathway through which psilocybin produces its antidepressant effects, and they found those effects persisting six months after a single dose. The findings point toward a concrete neurological mechanism, moving the conversation about psilocybin therapy from observed outcomes toward a clearer understanding of how and […]