Psilocybin and Anxiety: A Hippocampal Reset Theory

Psilocybin and anxiety mechanism: Resetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathology

A theoretical paper published in Psychopharmacology in 2026 proposes that anxiety disorders may involve a kind of stuck pattern in the hippocampus, a brain structure central to memory and context, and that psychedelics could work by temporarily disrupting that pattern. This is a theoretical framework, not a clinical trial, and no human therapeutic outcomes are […]

Psilocybin and Brain Entropy: Changes Lasting One Month

Psilocybin brain entropy: Psilocybin and Brain Entropy: Changes Lasting One Month

In a small controlled study of 28 healthy adults, a single 25 mg dose of psilocybin increased brain entropy during the experience, and participants reported greater psychological insight and improved well-being up to one month later. Structural imaging also showed changes in neural tract integrity. These are early findings in a healthy, non-clinical sample. Key […]