In a small pilot study of seven healthy adults, Washington University researchers used fMRI to show that psilocybin dramatically disrupts functional connectivity across the brain, especially in the default mode network, the system thought to govern a person’s sense of self, space, and time. Some connectivity changes persisted for at least three weeks. Key takeaways […]
A 2025 focus article published in the Journal of Pain proposes that psilocybin could act as a “psychophysical adaptogen” in chronic pain rehabilitation, potentially loosening what the authors call self-pain enmeshment and reducing psychological barriers to exercise engagement. This is a theoretical framework, not a clinical trial. Key takeaways Identity and pain are intertwined. The […]
New research published in June 2026 in the Proceedings of the National Academy of Sciences offers one of the clearest mechanistic pictures yet of what several psychedelic compounds have in common inside the brain. Using optical flow analysis, a technique that tracks the direction and strength of neural signal movement across the cortex, scientists from […]